The whole point of this challenge is that you cannot fire tears and only can use three items known as Bob’s Brain. BRAINS!īrains is often considered to be one of the fairest unfair challenges in this game. It sounds like a walk in the park besides one rule, you lose one item and one heart container every floor you ascend, and if you lose the item you were relying on, it may be the end of your run. In Backasswards, you spawn at one of the final bosses in the game with ten random items and a random amount of heart containers and must fight your way backwards from the final boss to the first-floor spawn room. In most games, Binding of Isaac included, the game is usually supposed to become harder the further it goes, right? This challenge flips that over onto its head. It is helped by a charge shot that helps you do more damage, but other than that, you need to be careful and aim well.
The game makes it very apparent that every shot counts now, because every time that a tear misses an enemy, fire, or something else in the environment, you take damage. In a game that often encourages throwing as many tears at the enemy as you can at enemies and hoping that one of them ends up killing it, Onan’s Streak comes out of nowhere to turn around the way that many people play the game. The whole challenge involves you dodging your own live grenades for way too many floors, and a constant hope that sooner or later, you’ll find something to make you immune to explosives. These both respectively make you throw giant explosive lobs around the room and make your own shots move away, then back towards you in a vicious arc of death. One of the few challenges that could be obtained in a normal run, this challenge is based on two items named Ipecac and My Reflection. The only ways you can deal damage are with the hairball flail on your tail and the flies spawned from hitting enemies with your hairball along with an item that spawns a few per room. In this challenge, Isaac is blindfolded and cannot fire any tears, which forces him to use an item attached to him known as Guppy’s Hairball. The main gimmick with his transformation is that you spawn friendly flies to do damage for you.
In the normal game, there is a transformation that you can turn into the cat of the namesake character, Guppy.
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